Proteolysis of blood coagulation factor X by activated factor X
نویسندگان
چکیده
منابع مشابه
Hereditary coagulation factor X deficiency.
Stuart Prower factor (Factor X) deficiency is a rare hereditary autosomal recessive coagulation disorder. We have come across three cases in the course of last 20 years at our institute. These patients presented with prolonged bleeding after minor trauma, epistaxis, subcutaneous bluish black nodules and two of them presented with history of consanguinity in parents. Hematological findings in co...
متن کاملRabbit plasma inhibitor of the activated species of blood coagulation factor X. Purification and some properties.
A naturally occurring inhibitor of activated blood coagulation Factor X has been isolated from pooled rabbit plasma and purified by the combination of Sephadex G-ZOO gel filtration, DEAE-Sephadex A-SO, and DEAE-cellulose chromatography. On microzone electrophoresis the purified product traveled as an az-globulin, and on 7.5% polyacrylamide gel disc electrophoresis at pH 9.5 it traveled as a sin...
متن کاملActivated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial cells.
PURPOSE To determine the transcriptional regulation of the blood coagulation factor X (FX) in cultured human retinal pigment epithelial (RPE) cells, and whether the effects of FXa on the chemotaxis and expression of angiogenic growth factors are mediated by autocrine growth factor signaling. METHODS Alterations in gene expression and secretion of growth factors were determined by real-time RT...
متن کاملCongenital factor X deficiency of coagulation revealed by epistaxis.
T congenital factor X (FX) is a plasmatic glycoprotein, which plays a crucial role in coagulation. Its deficit is among rare causes of the hemorrhage in child. It could be acquired or congenital. The main hemorrhagic manifestations are epistaxis, hematuria, and menorrhagia in females, sometimes hemarthrosis even craniocerebral hemorrhage. The measurement of the FX rate in the blood allows the d...
متن کاملThe contributions of Ca2+, phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII.
In the extrinsic pathway of blood coagulation, Factor X is activated by a complex of tissue factor, factor VII(a) and Ca2+ ions. Using purified human coagulation factors and a sensitive spectrophotometric assay for Factor Xa, we could demonstrate activation of Factor X by Factor VIIa in the absence of tissue-factor apoprotein, phospholipids and Ca2+. This finding allowed a kinetic analysis of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1982
ISSN: 0014-5793
DOI: 10.1016/0014-5793(82)80844-2